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KMID : 1033620120390010028
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Clinical and Experimental Reproductive Medicine
2012 Volume.39 No. 1 p.28 ~ p.32
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Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET
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Kim Jee-Hyun
Shin Mi-Sun
Yi Gwang
Jee Byung-Chul
Lee Jung-Ryeol
Suh Chang-Suk
Kim Seok-Hyun
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Abstract
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Objective: This study was performed to assess the prognostic value of serum hCG, progesterone, and inhibin A levels measured at 11 days post-ET for predicting pregnancy outcome in women participating in IVF.
Methods: Between May 2005 and April 2008, sera were obtained from 70 infertile women who underwent IVF-ET at 11 days post-ET and stored. HCG, progesterone, and inhibin A levels were measured by commercial enzyme-linked immunosorbent assay kits. The predictive accuracy of hCG, progesterone, and inhibin A levels for establishment of intrauterine pregnancy and ongoing pregnancy was calculated by receiver-operating characteristic curve analysis.
Results: For the prediction of intrauterine and ongoing pregnancy, serum hCG was better than progesterone and inhibin A. The predictive performance of progesterone and inhibin A was similar. The serum progesterone and inhibin A levels were significantly correlated each other (r=0.915, p=0.010).
Conclusion: A single measurement of the serum hCG level is sufficient to predict pregnancy outcome in IVF-ET patients.
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KEYWORD
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Chorionic gonadotropin, Progesterone, Inhibins, In vitro fertilization, Embryo transfer, Outcomes, pregnancy
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